Tang-Yuan Chu, M.D., Ph.D., Professor/Deputy Director

tychuEducation: Ph.D.,Cornell University Medical Center, New York, USA
Research Fields: 1.Cancer genetics and epigenetics  2.Cancer and stem cell development  3.Human papillomavirus and cervical cancer
E-mail: tychu@mail.tcu.edu.tw
TEL: 886-3-856-1825 ext.15610

 

Recent Publications:

  1. Huang YK, You SL, Yuan CC, Ke YM, Cao JM, Liao CY, Wu CH, Hsu CS, Huang KF, Lu CH, Twu NF, Chu TY* Long-term Outcomes of High Risk Human Papillomavirus Infection Supports a Long Interval of Cervical Cancer Screening. Br J Cancer, 2008 Mar 11;98(5):863-9. (SCI)
  2. Ding DC, Chu TY, Hsu YH. Multimodality therapy of squamous cell carcinoma arising mature cystic teratoma of ovary: A case report. Eur J Obstet Gynecol Reprod Biol.  2008 Apr;137(2):250-1. (SCI)
  3. Lin CT, Lai HC, Lee HY, Lin WH, Chang CC, Chu TY, Lin YW, Lee KD, Yu MH. Valproic acid resensitizes cisplatin-resistant ovarian cancer cells. Cancer Sci. 2008 Jun;99(6):1218-26. Epub 2008 Apr 21. (SCI)
  4. Lai HC, Lin YW, Huang TH, Yan P, Huang RL, Wang HC, Liu J, Chan MW, Chu TY, Sun CA, Chang CC, Yu MH. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008 Jul 1;123(1):161-7. (SCI)
  5. Chu TY*.  Risk factors and genetic markers of human papillomavirus-induced cervical carcinogenesis: a focus on Chinese populations in southeast Asia and southern China. Tzu Chi Med J. 2008.June. 20 (2).91-100.
  6. Tay SK, Ngan HY, Chu TY, Cheung AN, Tay EH. Epidemiology of human papillomavirus infection and cervical cancer and future perspectives in Hong Kong, Singapore and Taiwan. Vaccine. 2008 Aug 19;26 Suppl 12:M60-70.(SCI)
  7. Ding DC, Chu TY, Hsu YH. Recurrent squamous cell carcinoma of the uterine cervix in an abdominal incision 2.5 years after a radical hysterectomy. Taiwan J Obstet Gynecol. 2008 Sep;47(3):348-9. No abstract available. (SCI)
  8. Ding DC, Hsu HC, Huang RL, Lai HC, Lin CY, Yu MH, Chu TY*. Type-specific distribution of HPV along the full spectrum of cervical carcinogenesis in Taiwan: An indication of viral oncogenic potential. Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):245-51. (SCI)
  9. Ding DC, Chu TY, Kao SP, Chen PC, Wei YC. Laparoscopic management of tubal ectopic pregnancy. JSLS. 2008 Jul-Sep;12(3):273-6.
  10. Chung MT, Sytwu HK, Yan MD, Shih YL, Chang CC, Yu MH, Chu TY, Lai HC, Lin YW. Promoter methylation of SFRPs gene family in cervical cancer. Gynecol Oncol. 2009 Feb;112(2):301-6.(SCI)
  11. Liu CY, Chao TK, Su PH, Lee HY, Shih YL, Su HY, Chu TY, Yu MH, Lin YW, Lai HC. Characterization of LMX-1A as a metastasis suppressor in cervical cancer. J Pathol. 2009 Oct;219(2):222-31.(SCI)
  12. Wang KH, Liu HW, Lin SR, Ding DC, Chu TY*. Field methylation silencing of the protocadherin 10 gene in cervical carcinogenesis as a potential specific diagnostic test from cervical scrapings. Cancer Sci. 2009 Nov;100(11):2175-80. Epub 2009 Jul 17.(SCI)
  13. Ding DC, Chiang MH, Lai HC, Hsiung CA, Hsieh CY, Chu TY*. Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia. Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):215-20. Epub 2009 Oct 9.(SCI)
  14. Huang TH, Lai HC, Liu HW, Ding DC, Lin CJ, Chu TY* Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer invasion. Int J Gynecol Cancer, 2010.May;20(4):513-19.(SCI)
  15. Ding DC, Chu TY, Hsu YH. Lipoleiomyoma of the Uterus. Taiwan J Obstet Gynecol. 2010.Mar;49(1):94-6. (SCI)
  16. Kao SP, Chu TY, Ding DC. Low-resistance flow in a large adenomyomatous polyp mimicking a leiomyosarcoma. Taiwan J Obstet Gynecol. 2010 Mar;49(1):91-3. (SCI)
  17. Lin CJ, Lai HC, Wang KH, Hsiung CA, Liu HW, Ding DC, Hsieh CY, Chu TY*. Testing for methylated PCDH10 or WT1 is superior to HPV test in detecting CIN3 or more severe neoplasms in triages of ASCUS smear result. Am J Obstet Gynecol, 2011 Jan;204(1):21.e1-7.  2010 Sep 10. [Epub ahead of print] (SCI)
  18. Chow IH, Tang CH, You SL, Liao CH, Chu TY, Chen CJ, Chen CA, Pwu RF. Cost-effectiveness analysis of human papillomavirus DNA testing and Pap smear for cervical cancer screening in a publicly financed health-care system. Br J Cancer. 2010 Dec 7;103(12):1773-82. Epub 2010 Nov 23. (SCI)
  19. Chu TY*, Hsiung CA, Chen CA, Chou HH, Ho CM, Chien TY, Chang HJ, Chou CY, Liou JD, Kan YY, Hsieh CY. Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix. Gynecol Oncol. 2011 Mar;120(3):449-53. Epub 2010 Dec 8. (SCI)
  20. Ding DC, Chu TY. Brain and intramedullary spinal cord metastasis from squamous cell cervical carcinoma. Taiwan J Obstet Gynecol. 2010 Dec;49(4):525-7. No abstract available. (SCI)
  21. Hong MK, Lin YC, Wei YC, Chu TY*.Parathyroid adenoma with hypertensive crisis and intracerebral hemorrhage mimicking hemolysis, elevated liver enzymes, low platelets syndrome. Obstet Gynecol. 2011 Feb;117(2 Pt 2):498-500. (SCI)
  22. Ding DC, Chu TY, Chiou SH, Liu HW. Enhanced differentiation and clonogenicity of human endometrial polyp stem cells. Differentiation. 2011 Mar;81(3):172-80. Epub 2011 Jan 14. (SCI)
  23. Ding DC, Chang YC, Liu HW, Chu TY*. Long-term persistence of human papillomavirus in environments. Gynecol Oncol. 2011 Apr;121(1):148-51. Epub 2011 Jan 3. (SCI)
  24. Chu TY*; Taiwan Clinical Oncology Group. Re Re: Post-coital vaginal douching is risky for non-regression of low-grade squamous intraepithelial lesion of the cervix. Gynecol Oncol. 2011 Jul;122(1):203-4. Epub 2011 Apr 13.
  25. Ngan HY, Garland SM, Bhatla N, Pagliusi SR, Chan KK, Cheung AN, Chu TY, Domingo EJ, Qiao YL, Park JS, Tay EH, Supakarapongkul W. Asia oceania guidelines for the implementation of programs for cervical cancer prevention and control. J Cancer Epidemiol. 2011;2011:794861. Epub 2011 Apr 13. (SCI)
  26. Chan PK, Luk AC, Park JS, Smith-McCune KK, Palefsky JM, Konno R, Giovannelli L, Coutlée F, Hibbitts S, Chu TY, Settheetham-Ishida W, Picconi MA, Ferrera A, De Marco F, Woo YL, Raiol T, Piña-Sánchez P, Cheung JL, Bae JH, Chirenje MZ, Magure T, Moscicki AB, Fiander AN, Di Stefano R, Cheung TH, Yu MM, Tsui SK, Pim D, Banks L. Identification of human papillomavirus type 58 lineages and the distribution worldwide. J Infect Dis. 2011 Jun 1;203(11):1565-73. (SCI)
  27. Ding DC, Chu TY. Disseminated granulosa cell tumor of pelvis. Taiwan J Obstet Gynecol. 2011 Jun;50(2):236-9. No abstract available. (SCI)
  28. Hong MK, Liao CY, Chu TY, Chen PC, Ding DC. Internal pudendal artery injury during prolapse surgery using nonanchored mesh. J Minim Invasive Gynecol. 2011 Sep-Oct;18(5):678-81. (SCI)
  29. Lin YC, Chu TY, Ding DC. Synchronous primary ovarian granulosa cell tumor and endometrial cancer. Taiwan J Obstet Gynecol. 2011 Dec;50(4):546-8. No abstract available. (SCI)
  30. Ding DC, Chu TY. Laparoscopic diagnosis of tuberculous peritonitis mimicking ovarian malignancy. Taiwan J Obstet Gynecol. 2011 Dec;50(4):540-2. No abstract available. (SCI)
  31. Hong MK, Chu TY, Chen PC. Complete bilateral ureteral obstruction following retrograde catheterization and radical hysterectomy. Taiwan J Obstet Gynecol. 2011 Dec;50(4):531-3. No abstract available. (SCI)
  32. Su PH, Lin YW, Huang RL, Liao YP, Lee HY, Wang HC, Chao TK, Chen CK, Chan MW, Chu TY, Yu MH, Lai HC. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. Oncogene. 2013 Jan 3;32(1):15-26. Epub 2012 Feb 13. (SCI)
  33. Ding DC, Shyu WC, Lin SZ, Liu HW, Chiou SH, Chu TY*. Human umbilical cord mesenchymal stem cells support non-tumorigenic expansion of human embryonic stem cells. Cell Transplant. 2012;21(7):1515-27. (SCI)
  34. Huang RL, Chang CC, Su PH, Chen YC, Liao YP, Wang HC, Yo YT, Chao TK, Huang HC, Lin CY, Chu TY, Lai HC. Methylomic Analysis Identifies Frequent DNA Methylation of Zinc Finger Protein 582 (ZNF582) in Cervical Neoplasms. PLoS One. 2012;7(7):e41060. Epub 2012 Jul 16. (SCI)
  35. Chan PK, Zhang C, Park JS, Smith-McCune KK, Palefsky JM, Giovannelli L, Coutlée F, Hibbitts S, Konno R, Settheetham-Ishida W, Chu TY, Ferrera A, Alejandra Picconi M, De Marco F, Woo YL, Raiol T, Piña-Sánchez P, Bae JH, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Fiander AN, Capra G, Young Ki E, Tan Y, Chen Z, Burk RD, Chan MC, Cheung TH, Pim D, Banks L. Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.Int J Cancer. 2013 Jun 1;132(11):2528-36. Epub 2012 Nov 29. (SCI)
  36. Su CC, Tsai JP, Lin MN, Hsieh TC, Tseng RC, Chu TY*. High seroprevalence of human herpesvirus type 8 in patients with end-stage renal disease in Taiwan. J Clin Virol. 2013 Sep;58(1):89-93.(SCI)
  37. Ding DC, Chou HL, Hung WT, Liu HW, Chu TY*. Human adipose-derived stem cells cultured in keratinocyte serum free medium: Donor’s age does not affect the proliferation and differentiation capacities.J Biomed Sci. 2013 Aug 14;20(1):59. (SCI)
  38. Chu TY*, Chang YC, Ding DC. Cervicovaginal secretions protect from human papillomavirus infection: Effects of vaginal douching.Taiwan J Obstet Gynecol. 2013 Jun;52(2):241-5.(SCI)
  39. Huang TH, Chu TY* Repression of miR-126 and up-regulation of adrenomedullin in the stromal endothelium by cancer-stromal crosstalks confers angiogenesis of cervical cancer. Oncogene. 2013 Sep 16. doi: 10.1038/onc.2013.335. [Epub ahead of print]
  40. Hong MK, Chu TY, Wei YC, Ding DC. High success rate and considerable adverse events of pelvic prolapse surgery with Prolift: a single center experience. Taiwan J Obstet Gynecol. 2013 Sep;52(3):389-94.(SCI)
  41. Chen YC, Huang RL, Huang YK, Laio YP, Su PH, Wang HC, Chang CC, Lin YW, Yu MH, Chu TY, Lai HC. Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer. Int J Cancer. 2013 Dec 6. [Epub ahead of print](SCI).
  42. Chu TY*, Yang JT, Huang TH, Liu HW. Crosstalk with cancer-associated fibroblasts increases the growth and radiation survival of cervical cancer cells. Radiat Res. 2014 May;181(5):540-7.(SCI)
  43. Ding DC, Wu KC, Chou HL, Hung WT, Liu HW, Chu TY.Human infra-patellar fat pad-derived stromal cells have more potent differentiation capacity than other mesenchymal cells and can be enhanced by hyaluronan. Cell Transplant. 2014 May 21; [Epub ahead of print] (SCI)
  44. Ding DC, Chu TY, Hsu YH.Large-cell neuro-endocrine carcinoma associated with borderline mucinous tumor of the ovary. . Taiwan J Obstet Gynecol. 2014 Jun;53(2):270-2. (SCI) Cell Transplant.2014 May 21; [Epub ahead of print] (SCI)
  45. Ding DC, Chu TY, Hsu YH. Remission of anti-epiligrin cicatricial pemphigoid after excision of cervical adenocarcinoma. Cutan Pathol. 2014 Aug;41(8):692-3.(SCI)
  46. Lai HC, Ou YC, Chen TC, Huang HJ, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Hung YC, Wen KC, Yu MH, Wang KL.PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study. Cancer Med. 2014 Aug;3(4):1062-74.
  47. Su CC, Lai CL, Tsao SM, Lin MN, Chu TY*.High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma. Med Microbiol Immunol. 2014 Aug 15;[Epub ahead of print] (SCI)
  48. Lin H, Chen TC, Chang TC, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Yeh LS, Wen KC, Huang CY, Yu MH. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions – A Taiwanese Gynecologic Oncology Group (TGOG) study. Gynecol Oncol.2014 Oct;135(1):64-8. (SCI)
  49. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK.Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52-Variant Lineages. J Infect Dis. 2014 Nov 15;210(10):1600-4(SCI)
  50. Su CC, Tseng KC, Lin MN, Hsieh TC, Chu TY*.High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):55-62.(SCI)
  51. Wang KH, Lin CJ, Liu CJ, Liu DW, Huang RL, Ding DC, Weng CF, Chu TY. Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV. Cancer Med. Cancer Med. 2015 Jan;4(1):43-55. doi: 10.1002/cam4.335. Epub 2014 Nov 21.
  52. Su CC, Lai CL, Tsao SM, Lin MN, Hsieh TC, Lu JJ, Chu TY. High prevalence of human herpesvirus type 8 infection in patients with pulmonary tuberculosis in Taiwan. Clin Microbiol Infect. 2015 Mar;21(3):266.e5-7. doi: 10.1016/j.cmi.2014.10.015. Epub 2014 Oct 29.
  53. Qin CZ, Lv QL, Wu NY, Cheng L, Chu YC, Chu TY, Hu L, Cheng Y, Zhang X, Zhou HH. Mechanism-based inhibition of Alantolactone on human cytochrome P450 3A4 in vitro and activity of hepatic cytochrome P450 in mice. J Ethnopharmacol. 2015 Apr 7. pii: S0378-8741(15)00220-2. doi: 10.1016/j.jep.2015.03.061. [Epub ahead of print]
  54. Liou YL, Zhang Y, Liu Y, Cao L, Qin CZ, Zhang TL, Chang CF, Wang HJ, Lin SY,Chu TY, Zhang Y, Zhou HH.Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results.Clin Epigenetics. 2015 Apr 28;7(1):50. doi: 10.1186/s13148-015-0084-2. eCollection 2015.
  55. Ding DC, Chou HL, Chang YH, Hung WT, Liu HW, Chu TY.Characterization of HLA-G and related immunosuppressive effects in human umbilical cord stroma derived stem cells.Cell Transplant. 2015 Jun 3. [Epub ahead of print]
  56. Hong MK, Lee MH, Ding DC, Chu SC, Chu TY. High grade serous ovarian carcinoma with serous tubal intraepithelial carcinoma in a case presented with atypical glandular cell favor neoplasm cervical cytology and dermatomyositis.Taiwan J Obstet Gynecol. 2015 Apr;54(2):183-6. doi: 10.1016/j.tjog.2013.07.004.
  57. Chang CC, Ou YC, Wang KL, Chang TC, Cheng YM, Chen CH, Chu TY, Hsu ST, Liou WS, Chang YY, Wu HH, Chen TH, Lai HC. Triage of Atypical Glandular Cell by SOX1 and POU4F3 Methylation: A Taiwanese Gynecologic Oncology Group (TGOG) Study. PLoS One. 2015 Jun 9;10(6):e0128705. doi: 10.1371/journal.pone.0128705. eCollection 2015.
  58. Huang HS, Chu SC, Hsu CF, Chen PC, Ding DC, Chang MY, Chu TY. Manuscript title: Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis. Carcinogenesis. 2015 Nov;36(11):1419-28. dol:10.1093/carcin/bgv132.Epub 2015 Sep 10.(SCI)